Turmeric (Curcuma longa L.) has antiestrogenic effects that may interfere with the activity of the hypothalamic-pituitary axis, thereby disrupting estrogen production and influencing both uterine weight and diameter. This experiment investigated how turmeric extract affects uterine parameters in female white rats (Rattus norvegicus, Sprague Dawley strain). A total of 28 rats were assigned to four groups: the control group (C) received only H₂O. In contrast, treatment groups T1, T2, and T4 were administered turmeric extract at doses of 250 mg/Kg BW, 500 mg/Kg BW, and 1000 mg/Kg BW, respectively, each combined with 1 ml of H₂O. The treatments were given once daily for five days. Results indicated that turmeric extract at 250 mg/Kg BW and 1000 mg/Kg BW led to a significant reduction in both uterine weight and diameter. In summary, turmeric extract reduced uterine size and weight, indicating its antiestrogenic capability in female rats.
Eurasian Academy of Medicine and Dentistry