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Use of Animals in Experimental Pharmacology and the Three Rs Principle
Medications, as essential tools in healthcare, undergo laboratory evaluation before being applied in treatment. Since cellular and organ functions are largely consistent across animals and humans, many processes in animal cells mirror those in human cells. From a biological standpoint, humans are categorized as animals. In experimental pharmacology, animals are utilized to examine disease effects on living tissues, evaluate new treatments, including animal medications, and assist in the training of future health professionals and scientists. They have significantly contributed to research progress, enabling the discovery of various new drugs through animal experimentation. However, animal testing presents specific challenges, including issues related to animal procurement, the complexity of experimental procedures, strict regulatory guidelines, ethical concerns, and, frequently, the perspectives of students. Consequently, modern advancements, such as computer simulations, are increasingly being adopted as substitutes for animal use. This article highlights the role of animals in experimental pharmacology while also acknowledging proposed alternatives for pharmacology education.
Journal of Applied Pharmaceutical Technologies and Systems
Original Research | Open access | 10 January 2023 | Article: 22
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Advanced Characterization of Bio-Nano Systems Advanced Drug Delivery Technologies Automation, Robotics and Digitalization in Pharmaceutical Manufacturing Bio-Nano Environmental Monitoring and Remediation Bio-Nano Interfaces and Interactions Bio-Nano Reproducibility, Standardization, Quality and Regulation Bio-Nano Systems Bio-Nano Technologies for Food, Agriculture and Industrial Biotechnology Bio-Nano Translation, Scale-up and Manufacturing Bio-enabled and Bio-inspired Nanoscale Materials Bioactive Scaffolds and Biomimetic Materials Biocompatibility, Biodistribution and Degradation Bioelectronics and Nano-Bioelectronics Biological Information Transfer and Bio-inspired Communication Systems Biologics Manufacturing Technologies Biomaterials Biopharmaceutical Processing and Manufacturing Biosensors, Nanosensors and Bioanalytical Platforms Clinical and Biomedical Technologies Computational Modeling and Simulation of Bio-Nano Systems Controlled, Targeted and Responsive Delivery Platforms Data and Reporting Standards Diagnostic and Therapeutic Applications Drug Delivery Systems Drug Formulation and Dosage-form Development Environmental Fate and Risk Evaluation of Bio-Nano Materials Good Manufacturing Practice (GMP) and Manufacturing Compliance Green Pharmaceutical Engineering and Resource Efficiency Green and Sustainable Synthesis of Nanomaterials Interdisciplinary Health Sciences Lab-on-chip and Micro/Nanofluidic Systems Lyophilization Machine Learning and Data-driven Methods for Bio-Nano Systems Medical and Dental Applications Modeling, Simulation and Computational Methods for Pharmaceutical Processes Molecular and Nanoscale Communication Nano-Bio Imaging and Contrast Agents Nano-enabled Biomedical Technologies Nano-enabled Drug Delivery Nanobiotechnology and Bionanotechnology Nanomaterials for Biomedical and Biological Applications Nanomedicine and Nano-enabled Therapeutic Systems Nanopharmaceuticals Nanotechnology Nanotechnology in Dentistry and Oral Health Nanotoxicology and Bio-Nano Safety Assessment Open Science Optical and Photonic Bio-Nano Systems Pharmaceutical Contamination Control Pharmaceutical Engineering Pharmaceutical Manufacturing Sustainability Pharmaceutical Manufacturing Systems Pharmaceutical Manufacturing Technologies Pharmaceutical Materials and Excipients Pharmaceutical Nanotechnology Pharmaceutical Packaging and Container-closure Systems Pharmaceutical Particle Engineering and Processing Pharmaceutical Process Development Pharmaceutical Process Monitoring and Real-time Quality Assurance Pharmaceutical Process Optimization Pharmaceutical Process Validation Pharmaceutical Production Systems Pharmaceutical Production Technologies Pharmaceutical Quality Control and Quality Assurance Pharmaceutical Regulatory Science and Validation Studies Pharmaceutical Scale-up and Technology Transfer Pharmaceutical Stability, Storage and Cold Chain Pharmaceutical Supply, Distribution, Traceability and Serialization Pharmaceutical Technology Point-of-care Technologies Process Analytical Technology (PAT) Publication Ethics Quality and Production Technologies Quality by Design (QbD) and Design of Experiments Research Integrity Smart Materials with Nanoscale Structure or Function Sterile Manufacturing and Aseptic Processing Theranostics Tissue Engineering and Regenerative Medicine Translational Research Translational and Industrial Pharmaceutical Studies Wearable and Implantable Biointerfaces




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