<?xml version="1.0" encoding="UTF-8"?><doi_batch version="4.3.7" xmlns="http://www.crossref.org/schema/4.3.7" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.crossref.org/schema/4.3.7 http://www.crossref.org/schema/deposit/crossref4.3.7.xsd">
		<head>
		<doi_batch_id>eamdacademy.org-tM4h-1789536430-l990234093</doi_batch_id>
		<timestamp>1789536430</timestamp>
		<depositor>
			<depositor_name>Eurasian Academy of Medicine and Dentistry</depositor_name>
			<email_address>info@eamdacademy.org</email_address>
		</depositor>
		<registrant>Eurasian Academy of Medicine and Dentistry</registrant>
	</head>
	<body>
		<journal>
			<journal_metadata>
				<full_title>Journal of Applied Pharmaceutical Technologies and Systems</full_title>
				<abbrev_title>J Appl Pharm Technol Syst</abbrev_title>
				<issn>3149-9589</issn>
			</journal_metadata>
			<journal_issue>
				<publication_date>
					<year>2026</year>
				</publication_date>
				<journal_volume>
					<volume>5</volume>
				</journal_volume>
				<issue>2</issue>
			</journal_issue>
			<journal_article publication_type="full_text">
				<titles>
					<title>Crizotinib in Patients with Metastatic Non-Small Cell Lung Cancer Harboring ALK Mutations: Insights from a Single-Center Study</title>
				</titles>
								<contributors>
          					<person_name sequence="first" contributor_role="author">
            <given_name>Giulia</given_name>
            <surname>Romano</surname>
					</person_name>
          					<person_name sequence="additional" contributor_role="author">
            <given_name>Marco</given_name>
            <surname>Bianchi</surname>
					</person_name>
          					<person_name sequence="additional" contributor_role="author">
            <given_name>Paolo</given_name>
            <surname>Conti</surname>
					</person_name>
          				</contributors>
								<publication_date>
					<year>2026</year>
				</publication_date>
				<doi_data>
					<doi>10.68159/l990234093</doi>
					<resource>https://eamdacademy.org/pub/journal/3/article/l990234093</resource>
				</doi_data>
				<citation_list>
          					<citation key="rk-10.68159/l990234093-590175dd-2f7e-4207-9646-cb9c0d5fc5cb">
					  <unstructured_citation>Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7-33.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-b432321e-3daa-4d38-b351-02af286f6b61">
					  <unstructured_citation>Chu QS. Targeting non-small cell lung cancer: driver mutation beyond epidermal growth factor mutation and anaplastic lymphoma kinase fusion. Ther Adv Med Oncol. 2020;12:1758835919895756.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-ca2930bc-23fc-44a9-aa9b-ba26b930ecdc">
					  <unstructured_citation>Ferrara MG, Di Noia V, D&#039;Argento E, Vita E, Damiano P, Cannella A, et al. Oncogene-addicted non-small-cell lung cancer: treatment opportunities and future perspectives. Cancers (Basel). 2020;12(5):1196.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-eee6f23e-d553-4a6b-9a65-8245daddbc99">
					  <unstructured_citation>De Mello RA, Neves NM, Tadokoro H, Amaral GA, Castelo-Branco P, Zia VAA. New target therapies in advanced non-small cell lung cancer: a review of the literature and future perspectives. J Clin Med. 2020;9(11):3543.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-75c7ae1f-e2f1-407e-835d-29f443e2d47a">
					  <unstructured_citation>Pikor LA, Ramnarine VR, Lam S, Lam WL. Genetic alterations defining NSCLC subtypes and their therapeutic implications. Lung Cancer. 2013;82(2):179-89.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-39453546-5806-4ea6-b682-0413d35e87b4">
					  <unstructured_citation>Chevallier M, Borgeaud M, Addeo A, Friedlaender A. Oncogenic driver mutations in non-small cell lung cancer: past, present and future. World J Clin Oncol. 2021;12(4):217-37.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-9853646d-9463-49e6-8fcc-b11ceabc2c51">
					  <unstructured_citation>Shaw AT, Yeap BY, Mino-Kenudson M, Digumarthy SR, Costa DB, Heist RS, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol. 2009;27(26):4247-53.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-f064ace4-88de-408e-9a86-72e9f6364b7c">
					  <unstructured_citation>Mohan A, Garg A, Gupta A, Sahu S, Choudhari C, Vashistha V, et al. Clinical profile of lung cancer in North India: a 10-year analysis of 1862 patients from a tertiary care center. Lung India. 2020;37(3):190-7.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-eb56a9ff-e72b-41f3-a1c1-5f069ce9eb25">
					  <unstructured_citation>Wang L, Sheng Z, Zhang J, Song J, Teng L, Liu L, et al. Comparison of lorlatinib, alectinib and brigatinib in ALK inhibitor-naive/untreated ALK-positive advanced non-small-cell lung cancer: a systematic review and network meta-analysis. J Chemother. 2022;34(2):87-96.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-d8821338-4e17-4a6a-b6c4-0ef5ee15f157">
					  <unstructured_citation>Xu H, Ma D, Yang G, Li J, Hao X, Xing P, et al. Sequential therapy according to distinct disease progression patterns in advanced ALK-positive non-small-cell lung cancer after crizotinib treatment. Chin J Cancer Res. 2019;31(2):349-56.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-7531a2d1-2f72-4467-887b-9e4c17773ecb">
					  <unstructured_citation>Solomon BJ, Mok T, Kim DW, Wu YL, Nakagawa K, Mekhail T, et al. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med. 2014;371(23):2167-77.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-b26e5b64-1542-49f6-b1ca-0c1174d8c28c">
					  <unstructured_citation>Solomon BJ, Kim DW, Wu YL, Nakagawa K, Mekhail T, Felip E, et al. Final overall survival analysis from a study comparing first-line crizotinib versus chemotherapy in ALK-Mutation-Positive Non-Small-Cell Lung Cancer. J Clin Oncol. 2018;36(22):2251-8.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-9ee1e38b-cf31-444f-bc69-b6c15e0ca75f">
					  <unstructured_citation>Mok T, Camidge DR, Gadgeel SM, Rosell R, Dziadziuszko R, Kim DW, et al. Updated overall survival and final progression-free survival data for patients with treatment-naive advanced ALK-positive non-small-cell lung cancer in the ALEX study. Ann Oncol. 2020;31(8):1056-64.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-835fc4a5-13e9-4f1c-8bc5-1340b059bf60">
					  <unstructured_citation>Camidge DR, Kim HR, Ahn MJ, Yang JCH, Han JY, Hochmair MJ, et al. Brigatinib versus crizotinib in ALK inhibitor-naive advanced ALK-Positive NSCLC: final results of phase 3 ALTA-1L trial. J Thorac Oncol. 2021;16(12):2091-08.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-e21cdbd2-d4e5-4484-9d5f-f1f7fb3afe30">
					  <unstructured_citation>Novello S, Mazieres J, Oh IJ, de Castro J, Migliorino MR, Helland A, et al. Alectinib versus chemotherapy in crizotinib-pretreated anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer: results from the phase III ALUR study. Ann Oncol. 2018;29(6):1409-16.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-1ce6f593-34ff-498c-925f-ca614b3f323e">
					  <unstructured_citation>Huber RM, Hansen KH, Paz-Ares Rodriguez L, West HL, Reckamp KL, Leighl NB, et al. Brigatinib in crizotinib-refractory ALK+ NSCLC: 2-Year follow-up on systemic and intracranial outcomes in the Phase 2 ALTA trial. J Thorac Oncol. 2020;15(3):404-15.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-8fdcd5fa-b813-41bb-9a20-ab1b19ba81d3">
					  <unstructured_citation>Solomon BJ, Besse B, Bauer TM, Felip E, Soo RA, Camidge DR, et al. Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 study. Lancet Oncol. 2018;19(12):1654- 67.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-501e1005-3e36-4c65-bd9a-7c493f6ad696">
					  <unstructured_citation>Katayama R, Shaw AT, Khan TM, Mino-Kenudson M, Solomon BJ, Halmos B, et al. Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. Sci Transl Med. 2012;4(120):120ra117.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-e5c2be6c-237d-4678-9655-15c42770b48b">
					  <unstructured_citation>Soria JC, Ho SN, Varella-Garcia M, Iafrate AJ, Solomon BJ, Shaw AT, et al. Correlation of extent of ALK FISH positivity and crizotinib efficacy in three prospective studies of ALK-positive patients with non-small-cell lung cancer. Ann Oncol. 2018;29(9):1964-71.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-bc50d9c5-251a-4db2-b991-2a09d23bee81">
					  <unstructured_citation>Yoshida T, Oya Y, Tanaka K, Shimizu J, Horio Y, Kuroda H, et al. Differential crizotinib response duration among ALK fusion variants in ALK-Positive Non-Small-Cell Lung Cancer. J Clin Oncol. 2016;34(28):3383-9.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/l990234093-d1daef6b-d542-4cb7-977f-6cf73b3adfca">
					  <unstructured_citation>Ock CY, Yoo SH, Keam B, Kim M, Kim TM, Jeon YK, et al. Clinical factors affecting progression-free survival with crizotinib in ALK-positive non-small cell lung cancer. Korean J Intern Med. 2019;34(5):1116-24.</unstructured_citation>
											</citation>
          				</citation_list>
			</journal_article>
		</journal>
	</body>
</doi_batch>
