<?xml version="1.0" encoding="UTF-8"?><doi_batch version="4.3.7" xmlns="http://www.crossref.org/schema/4.3.7" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.crossref.org/schema/4.3.7 http://www.crossref.org/schema/deposit/crossref4.3.7.xsd">
		<head>
		<doi_batch_id>eamdacademy.org-FZQP-1790527728-k699635774</doi_batch_id>
		<timestamp>1790527728</timestamp>
		<depositor>
			<depositor_name>Eurasian Academy of Medicine and Dentistry</depositor_name>
			<email_address>info@eamdacademy.org</email_address>
		</depositor>
		<registrant>Eurasian Academy of Medicine and Dentistry</registrant>
	</head>
	<body>
		<journal>
			<journal_metadata>
				<full_title>Journal of Applied Pharmaceutical Technologies and Systems</full_title>
				<abbrev_title>J Appl Pharm Technol Syst</abbrev_title>
				<issn>3149-9589</issn>
			</journal_metadata>
			<journal_issue>
				<publication_date>
					<year>2026</year>
				</publication_date>
				<journal_volume>
					<volume>5</volume>
				</journal_volume>
				<issue>1</issue>
			</journal_issue>
			<journal_article publication_type="full_text">
				<titles>
					<title>Therapeutic Synchronization of Drug Release Profiles with Disease Rhythms, Patient Behavior, and Care Pathways</title>
				</titles>
								<contributors>
          					<person_name sequence="first" contributor_role="author">
            <given_name>Emily</given_name>
            <surname>Johnson</surname>
					</person_name>
          					<person_name sequence="additional" contributor_role="author">
            <given_name>Robert</given_name>
            <surname>Smith</surname>
					</person_name>
          					<person_name sequence="additional" contributor_role="author">
            <given_name>Laura</given_name>
            <surname>Brown</surname>
					</person_name>
          					<person_name sequence="additional" contributor_role="author">
            <given_name>Kevin</given_name>
            <surname>Miller</surname>
					</person_name>
          				</contributors>
								<publication_date>
					<year>2026</year>
				</publication_date>
				<doi_data>
					<doi>10.68159/k699635774</doi>
					<resource>https://eamdacademy.org/pub/journal/3/article/k699635774</resource>
				</doi_data>
				<citation_list>
          					<citation key="rk-10.68159/k699635774-c53d3642-9296-4d3f-9443-326468fcfd0c">
					  <unstructured_citation>Ballesta A, Innominato PF, Dallmann R, Rand DA, Lévi FA. Systems chronotherapeutics. Pharmacol Rev. 2017;69(2):161-99.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-e3524b8e-063d-4c1c-8395-6c9f126bfa68">
					  <unstructured_citation>Cederroth CR, Albrecht U, Bass J, Brown SA, Dyhrfjeld-Johnsen J, Gachon F, et al. Medicine in the fourth dimension. Cell Metab. 2019;30(2):238-50.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-dca3ac34-5a7f-48b3-bef3-b8b19129c258">
					  <unstructured_citation>Bicker J, Alves G, Falcão A, Fortuna A. Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics. Br J Pharmacol. 2020;177(10):2215-39.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-275f3452-24e5-4e71-ae94-2b183aa0bb31">
					  <unstructured_citation>Ayyar VS, Sukumaran S. Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions. J Pharmacokinet Pharmacodyn. 2021;48(3):321-38.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-d4aae7a1-4332-481e-88fc-01b10899db13">
					  <unstructured_citation>Ohdo S, Koyanagi S, Matsunaga N. Chronopharmacological strategies focused on chrono-drug discovery. Pharmacol Ther. 2019;202:72-90.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-a20f1bf3-ed7c-4270-8f1a-c9dba9c10b99">
					  <unstructured_citation>Butler CT, Rodgers AM, Curtis AM, Donnelly RF. Chrono-tailored drug delivery systems: recent advances and future directions. Drug Deliv Transl Res. 2024;14(7):1756-75.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-706b51ed-bda3-4451-8202-228aaac0e1e8">
					  <unstructured_citation>Yu J, Zhang Y, Yan J, Kahkoska AR, Gu Z. Advances in bioresponsive closed-loop drug delivery systems. Int J Pharm. 2018;544(2):350-7.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-680bb1e1-0c39-4160-ba7e-381a1751f072">
					  <unstructured_citation>Komashie A, Ward J, Bashford T, Dickerson T, Kaya GK, Liu Y, et al. Systems approach to health service design, delivery and improvement: a systematic review and meta-analysis. BMJ Open. 2021;11(1):e037667.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-f5adc914-dfb0-4428-8bdd-887f4f039121">
					  <unstructured_citation>Kramer A, Lange T, Spies C, Finger AM, Berg D, Oster H. Foundations of circadian medicine. PLoS Biol. 2022;20(3):e3001567.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-eafc3c7d-e6b6-4ef7-a8fb-be56e9f422d7">
					  <unstructured_citation>Stewart SJ, Moon Z, Horne R. Medication nonadherence: health impact, prevalence, correlates and interventions. Psychol Health. 2023;38(6):726-65.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-3f518f7b-cd03-4345-85d7-1e2b4f017a5a">
					  <unstructured_citation>Mason M, Cho Y, Rayo J, Gong Y, Harris M, Jiang Y. Technologies for medication adherence monitoring and technology assessment criteria: narrative review. JMIR Mhealth Uhealth. 2022;10(3):e35157.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-7a106c26-ba90-443d-b7b5-eaf1b564c104">
					  <unstructured_citation>Vargason AM, Anselmo AC, Mitragotri S. The evolution of commercial drug delivery technologies. Nat Biomed Eng. 2021;5(9):951-67.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-fc50765d-4a0e-4405-ac46-62bb442a380d">
					  <unstructured_citation>Albuquerque T, Neves AR, Quintela T, Costa D. Exploring the link between chronobiology and drug delivery: Effects on cancer therapy. J Mol Med. 2021;99(10):1349-71.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-746b8297-9a9e-484c-a9bd-8de771d5538f">
					  <unstructured_citation>Amiama-Roig A, Verdugo-Sivianes EM, Carnero A, Blanco JR. Chronotherapy: circadian rhythms and their influence in cancer therapy. Cancers. 2022;14(20):5071.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-5f9f62da-1c3a-471e-91ba-2c285c158591">
					  <unstructured_citation>Manikkath J, Subramony JA. Toward closed-loop drug delivery: Integrating wearable technologies with transdermal drug delivery systems. Adv Drug Deliv Rev. 2021;179:113997.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-28f52e60-4351-4523-bc05-0c53faf87ef1">
					  <unstructured_citation>Clarkson J, Dean J, Ward J, Komashie A, Bashford T. A systems approach to healthcare: from thinking to practice. Future Healthc J. 2018;5(3):151-5.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-6acf540a-6df5-47e4-aae6-0b10d067c857">
					  <unstructured_citation>Lévi FA, Okyar A, Hadadi E, Innominato PF, Ballesta A. Circadian regulation of drug responses: toward sex-specific and personalized chronotherapy. Annu Rev Pharmacol Toxicol. 2024;64(1):89-114.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-1e7756ad-015d-4c98-acf8-4d83bc49805c">
					  <unstructured_citation>Aldeer M, Javanmard M, Martin RP. A review of medication adherence monitoring technologies. Appl Syst Innov. 2018;1(2):14.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-35d9c38c-115e-4bcd-9e52-bf38b7314d58">
					  <unstructured_citation>Zhang A, Jung K, Li A, Liu J, Boyer C. Recent advances in stimuli-responsive polymer systems for remotely controlled drug release. Prog Polym Sci. 2019;99:101164.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-aa57ca51-6b4d-458c-855d-6ed48756d6ad">
					  <unstructured_citation>Yu J, Zhang Y, Kahkoska AR, Gu Z. Bioresponsive transcutaneous patches. Curr Opin Biotechnol. 2017;48:28-32.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-0078d2de-4b0b-4713-804b-568f49584b54">
					  <unstructured_citation>Amjadi M, Sheykhansari S, Nelson BJ, Sitti M. Recent advances in wearable transdermal delivery systems. Adv Mater. 2018;30(7):1704530.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-8b21c262-4f15-4aee-abaf-9bc34a67869d">
					  <unstructured_citation>Del Bono F, Di Trani N, Demarchi D, Grattoni A, Ros PM. Active implantable drug delivery systems: engineering factors, challenges, opportunities. Lab Chip. 2025;25(15):3608-29.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-07d7c175-941b-445a-aebf-0b926fab44a8">
					  <unstructured_citation>Moon Z, Walsh J. Digital interventions in medication adherence: A narrative review of current evidence and challenges. Front Pharmacol. 2025;16:1632474.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-e26b30b6-5c35-4a79-b6c8-95eea62305a9">
					  <unstructured_citation>Chai PR, Vaz C, Goodman GR, Albrechta H, Huang H, Rosen RK, et al. Ingestible electronic sensors to measure instantaneous medication adherence: A narrative review. Digit Health. 2022;8:20552076221083119.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/k699635774-7115236c-0587-455f-9f05-ea0481524b7c">
					  <unstructured_citation>Wells CM, Harris M, Choi L, Murali VP, Guerra FD, Jennings JA. Stimuli-responsive drug release from smart polymers. J Funct Biomater. 2019;10(3):34.</unstructured_citation>
											</citation>
          				</citation_list>
			</journal_article>
		</journal>
	</body>
</doi_batch>
