<?xml version="1.0" encoding="UTF-8"?><doi_batch version="4.3.7" xmlns="http://www.crossref.org/schema/4.3.7" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.crossref.org/schema/4.3.7 http://www.crossref.org/schema/deposit/crossref4.3.7.xsd">
		<head>
		<doi_batch_id>eamdacademy.org-3onf-1794452424-g935757564</doi_batch_id>
		<timestamp>1794452424</timestamp>
		<depositor>
			<depositor_name>Eurasian Academy of Medicine and Dentistry</depositor_name>
			<email_address>info@eamdacademy.org</email_address>
		</depositor>
		<registrant>Eurasian Academy of Medicine and Dentistry</registrant>
	</head>
	<body>
		<journal>
			<journal_metadata>
				<full_title>Journal of Applied Pharmaceutical Technologies and Systems</full_title>
				<abbrev_title>J Appl Pharm Technol Syst</abbrev_title>
				<issn>3149-9589</issn>
			</journal_metadata>
			<journal_issue>
				<publication_date>
					<year>2026</year>
				</publication_date>
				<journal_volume>
					<volume>5</volume>
				</journal_volume>
				<issue>1</issue>
			</journal_issue>
			<journal_article publication_type="full_text">
				<titles>
					<title>Technological Lock-In in Advanced Drug Delivery Systems and Its Role in Translational Failure</title>
				</titles>
								<contributors>
          					<person_name sequence="first" contributor_role="author">
            <given_name>Victor</given_name>
            <surname>Santos</surname>
					</person_name>
          					<person_name sequence="additional" contributor_role="author">
            <given_name>Rafael</given_name>
            <surname>Costa</surname>
					</person_name>
          					<person_name sequence="additional" contributor_role="author">
            <given_name>Bruno</given_name>
            <surname>Teixeira</surname>
					</person_name>
          				</contributors>
								<publication_date>
					<year>2026</year>
				</publication_date>
				<doi_data>
					<doi>10.68159/g935757564</doi>
					<resource>https://eamdacademy.org/pub/journal/3/article/g935757564</resource>
				</doi_data>
				<citation_list>
          					<citation key="rk-10.68159/g935757564-235f19c2-7369-46e2-b440-266ba71d4b0d">
					  <unstructured_citation>Hare JI, Lammers T, Ashford MB, Puri S, Storm G, Barry ST, et al. Challenges and strategies in anti-cancer nanomedicine development: An industry perspective. Adv Drug Deliv Rev. 2017;108:25-38.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-52e7ffcf-8c64-49de-a159-860451f4c065">
					  <unstructured_citation>Agrahari V, Agrahari V. Facilitating the translation of nanomedicines to a clinical product: challenges and opportunities. Drug Discov Today. 2018;23(5):974-91.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-0a8c4c5f-4d15-461f-932c-50d5cb90619d">
					  <unstructured_citation>Faria M, Björnmalm M, Thurecht KJ, Kent SJ, Parton RG, Kavallaris M, et al. Minimum information reporting in bio–nano experimental literature. Nat Nanotechnol. 2018;13(9):777-85.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-92d4bb13-0b3a-43c5-b1d1-909559dfd442">
					  <unstructured_citation>Anselmo AC, Mitragotri S. Nanoparticles in the clinic: An update. Bioeng Transl Med. 2019;4(3):e10143.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-3653c3e5-0183-4f66-aa2c-ee71ff0ce542">
					  <unstructured_citation>Akinc A, Maier MA, Manoharan M, Fitzgerald K, Jayaraman M, Barros S, et al. The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs. Nat Nanotechnol. 2019;14(12):1084-7.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-4309d82b-a4ec-4d4b-b689-f8bb2876cef0">
					  <unstructured_citation>He H, Liu L, Morin EE, Liu M, Schwendeman A. Survey of clinical translation of cancer nanomedicines—lessons learned from successes and failures. Acc Chem Res. 2019;52(9):2445-61.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-a1787743-976f-49f3-b4ec-9a7f09c0c57e">
					  <unstructured_citation>Guidolin K, Zheng G. Nanomedicines lost in translation. ACS Nano. 2019;13(12):13620-6.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-6f90e2e3-181c-4b61-9201-554cbac152ed">
					  <unstructured_citation>Sindhwani S, Syed AM, Ngai J, Kingston BR, Maiorino L, Rothschild J, et al. The entry of nanoparticles into solid tumours. Nat Mater. 2020;19(5):566-75.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-cd9cab4b-bc88-4438-b363-e3adbb055d4c">
					  <unstructured_citation>Mohamed M, Abu Lila AS, Shimizu T, Alaaeldin E, Hussein A, Sarhan HA, et al. PEGylated liposomes: immunological responses. Sci Technol Adv Mater. 2019;20(1):710-24.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-01d1ba04-63bd-4980-916e-ce97ed820b71">
					  <unstructured_citation>Germain M, Caputo F, Metcalfe S, Tosi G, Spring K, Åslund AK, et al. Delivering the power of nanomedicine to patients today. J Control Release. 2020;326:164-71.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-bb416b79-64fc-4440-8847-0abd9b8d15fb">
					  <unstructured_citation>Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2021;20(2):101-24.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-92243544-6ae2-41fd-8794-c24aeff391e8">
					  <unstructured_citation>Younis MA, Tawfeek HM, Abdellatif AA, Abdel-Aleem JA, Harashima H. Clinical translation of nanomedicines: Challenges, opportunities, and keys. Adv Drug Deliv Rev. 2022;181:114083.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-00d70556-1c6f-4b84-ba8c-1ff4d9edbde8">
					  <unstructured_citation>Kulkarni JA, Witzigmann D, Chen S, Cullis PR, Van Der Meel R. Lipid nanoparticle technology for clinical translation of siRNA therapeutics. Acc Chem Res. 2019;52(9):2435-44.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-df63388c-5415-4e91-9d9c-17213022dc2e">
					  <unstructured_citation>Shi Y, Van der Meel R, Chen X, Lammers T. The EPR effect and beyond: Strategies to improve tumor targeting and cancer nanomedicine treatment efficacy. Theranostics. 2020;10(17):7921.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-45a122b5-626b-4225-af9f-82e5276c411c">
					  <unstructured_citation>Đorđević S, Gonzalez MM, Conejos-Sánchez I, Carreira B, Pozzi S, Acúrcio RC, et al. Current hurdles to the translation of nanomedicines from bench to the clinic. Drug Deliv Transl Res. 2022;12(3):500-25.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-ba722c9d-6040-4583-b77f-a273e0d6605f">
					  <unstructured_citation>Shan X, Gong X, Li J, Wen J, Li Y, Zhang Z. Current approaches of nanomedicines in the market and various stage of clinical translation. Acta Pharm Sin B. 2022;12(7):3028-48.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-e65d1687-5bb5-4f1e-accb-fb723c5da01b">
					  <unstructured_citation>Wang G, Wang N, Xia X, Ismail M, Shi B. Clinical translation of nanomedicines for brain diseases: Current challenges and future directions. J Control Release. 2025;114426.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-b0b5fabf-6628-41bb-b71a-a7eb027ecca6">
					  <unstructured_citation>Joyce P, Allen CJ, Alonso MJ, Ashford M, Bradbury MS, Germain M, et al. A translational framework to DELIVER nanomedicines to the clinic. Nat Nanotechnol. 2024;19(11):1597-611.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-1d90df4f-3d06-43d4-9aab-f4fb6e603f6d">
					  <unstructured_citation>Zhang P, Xiao Y, Sun X, Lin X, Koo S, Yaremenko AV, et al. Cancer nanomedicine toward clinical translation: Obstacles, opportunities, and future prospects. Med. 2023;4(3):147-67.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-5547c158-2945-44a9-94d9-2e81f3bf39db">
					  <unstructured_citation>Tong F, Wang Y, Gao H. Progress and challenges in the translation of cancer nanomedicines. Curr Opin Biotechnol. 2024;85:103045.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-fdaa5e95-0774-4e5d-96ca-a216cc604a72">
					  <unstructured_citation>Wolfram J, Ferrari M. Clinical cancer nanomedicine. Nano Today. 2019;25:85-98.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-c8e0c380-79b4-4c58-8519-46f3166eb621">
					  <unstructured_citation>Couvreur P. Nanomedicine: From where are we coming and where are we going? J Control Release. 2019;311:319-21.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-4a3dd48d-0577-4001-9a59-4f542ba0d81e">
					  <unstructured_citation>Ikeda-Imafuku M, Wang LL, Rodrigues D, Shaha S, Zhao Z, Mitragotri S. Strategies to improve the EPR effect: a mechanistic perspective and clinical translation. J Control Release. 2022;345:512-36.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-571e85f4-319a-4c12-ac02-0184519edd82">
					  <unstructured_citation>Hou X, Zaks T, Langer R, Dong Y. Lipid nanoparticles for mRNA delivery. Nat Rev Mater. 2021;6(12):1078-94.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-bf045144-22dd-40f0-ae4d-f33741cb4c05">
					  <unstructured_citation>Souri M, Soltani M, Kashkooli FM, Shahvandi MK, Chiani M, Shariati FS, et al. Towards principled design of cancer nanomedicine to accelerate clinical translation. Mater Today Bio. 2022;13:100208.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-78d08a04-132a-473f-b55e-fc2c5d1cc41f">
					  <unstructured_citation>Hua S, De Matos MB, Metselaar JM, Storm G. Current trends and challenges in the clinical translation of nanoparticulate nanomedicines: pathways for translational development and commercialization. Front Pharmacol. 2018;9:790.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-b8f684e0-6272-4c27-b186-ae1169210920">
					  <unstructured_citation>Soares S, Sousa J, Pais A, Vitorino C. Nanomedicine: principles, properties, and regulatory issues. Front Chem. 2018;6:360.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-af4646ed-9ef3-443b-be03-b7d69f8d394a">
					  <unstructured_citation>Lammers T, Ferrari M. The success of nanomedicine. Nano Today. 2020;31:100853.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-c235563d-05eb-4996-a010-c192c172a733">
					  <unstructured_citation>Metselaar JM, Lammers T. Challenges in nanomedicine clinical translation. Drug Deliv Transl Res. 2020;10(3):721-5.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-3d179240-fa75-4611-bc18-a590be344860">
					  <unstructured_citation>Wu J. The enhanced permeability and retention (EPR) effect: the significance of the concept and methods to enhance its application. J Pers Med. 2021;11(8):771.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-015afac1-ece1-4273-81bd-e3928c7f8ed4">
					  <unstructured_citation>Pallares RM, Barmin RA, Wang A, Kiessling F, Lammers T. Clinical cancer nanomedicines. J Control Release. 2025;385:113991.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-35418b6f-3d68-4348-b36a-ac8c2646c602">
					  <unstructured_citation>Hoang Thi TT, Pilkington EH, Nguyen DH, Lee JS, Park KD, Truong NP. The importance of poly (ethylene glycol) alternatives for overcoming PEG immunogenicity in drug delivery and bioconjugation. Polymers (Basel). 2020;12(2):298.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/g935757564-9f6c8c48-d2fc-446d-99be-71eb137717b7">
					  <unstructured_citation>Kozma GT, Shimizu T, Ishida T, Szebeni J. Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals. Adv Drug Deliv Rev. 2020;154:163-75.</unstructured_citation>
											</citation>
          				</citation_list>
			</journal_article>
		</journal>
	</body>
</doi_batch>
