eamdacademy.org-vTj2-1792280467-f772334574 1792280467 Eurasian Academy of Medicine and Dentistry info@eamdacademy.org Eurasian Academy of Medicine and Dentistry Journal of Applied Pharmaceutical Technologies and Systems J Appl Pharm Technol Syst 3149-9589 2026 5 2 Alejandro Torres Miguel Fernandez 2026 10.68159/f772334574 https://eamdacademy.org/pub/journal/3/article/f772334574 Ding B. Pharma Industry 4.0: Literature review and research opportunities in sustainable pharmaceutical supply chains. Process Saf Environ Prot. 2018;119:115-30. Reinhardt IC, Oliveira JC, Ring DT. Current perspectives on the development of industry 4.0 in the pharmaceutical sector. J Ind Inf Integr. 2020;18:100131. Chen Y, Yang O, Sampat C, Bhalode P, Ramachandran R, Ierapetritou M, et al. Digital twins in pharmaceutical and biopharmaceutical manufacturing: a literature review. Processes. 2020;8(9):1088. Martinetz MC, Karttunen AP, Sacher S, Wahl P, Ketolainen J, Khinast JG, et al. RTD-based material tracking in a fully-continuous dry granulation tableting line. Int J Pharm. 2018;547(1-2):469-79. Karttunen AP, Hörmann TR, De Leersnyder F, Ketolainen J, De Beer T, Hsiao WK, et al. Measurement of residence time distributions and material tracking on three continuous manufacturing lines. Int J Pharm. 2019;563:184-97. Kim EJ, Kim JH, Kim MS, Jeong SH, Choi DH. Process analytical technology tools for monitoring pharmaceutical unit operations: a control strategy for continuous process verification. Pharmaceutics. 2021;13(6):919. Sacher S, Poms J, Rehrl J, Khinast JG. PAT implementation for advanced process control in solid dosage manufacturing–a practical guide. Int J Pharm. 2022;613:121408. Kruisz J, Rehrl J, Faulhammer E, Witschnigg A, Khinast JG. Material tracking in a continuous direct capsule-filling process via residence time distribution measurements. Int J Pharm. 2018;550(1-2):347-58. Bamakan SM, Moghaddam SG, Manshadi SD. Blockchain-enabled pharmaceutical cold chain: Applications, key challenges, and future trends. J Clean Prod. 2021;302:127021. Singh R, Dwivedi AD, Srivastava G. Internet of things based blockchain for temperature monitoring and counterfeit pharmaceutical prevention. Sensors. 2020;20(14):3951. Zabczyk C, Blakey JD. The effect of connected “smart” inhalers on medication adherence. Front Med Technol. 2021;3:657321. Chai PR, Vaz C, Goodman GR, Albrechta H, Huang H, Rosen RK, et al. Ingestible electronic sensors to measure instantaneous medication adherence: A narrative review. Digit Health. 2022;8:20552076221083119. Celikovic S, Rehrl J, Fraga RM, Steinberger M, Khinast J, Horn M, et al. A modern strategy for digital real-time release testing in continuous tablet manufacturing. Eur J Pharm Biopharm. 2025;211:114700. Phalak P, Tomba E, Jehoulet P, Kapitan-Gnimdu A, Soladana PM, Vagaggini L, et al. Digital twin implementation for manufacturing of adjuvants. Processes. 2023;11(6):1717. Raudenbusha K, Malinova N, Reddya JV, Dinga C, Tiana H, Ierapetritoua M. Towards the development of digital twin for pharmaceutical manufacturing. Pharm Manuf J. 2024. Juckers A, Knerr P, Harms F, Strube J. Digital twin enabled process development, optimization and control in lyophilization for enhanced biopharmaceutical production. Processes. 2024;12(1):211. Vega-Zambrano C, Diangelakis NA, Charitopoulos VM. Data-driven model predictive control for continuous pharmaceutical manufacturing. Int J Pharm. 2025;672:125322. Sim C, Zhang H, Chang ML. Improving end-to-end traceability and pharma supply chain resilience using blockchain. Blockchain Healthc Today. 2022;5:10-30953. Dasaklis TK, Voutsinas TG, Tsoulfas GT, Casino F. A systematic literature review of blockchain-enabled supply chain traceability implementations. Sustainability. 2022;14(4):2439. Namasudra S, Das S, Crespo RG, Taniar D, Moparthi NR. DrugBlock: An advanced system to secure drug supply chain using Internet of Things and blockchain-enabled consumer electronics. IEEE Trans Consum Electron. 2024;71(2):4497-507. Garin N, Zarate-Tamames B, Gras-Martin L, Mila R, Crespo-Lessmann A, Curto E, et al. Clinical impact of electronic monitoring devices of inhalers in adults with asthma or COPD: a systematic review and meta-analysis. Pharmaceuticals. 2023;16(3):414. Aung H, Tan R, Flynn C, Divall P, Wright A, Murphy A, et al. Digital remote maintenance inhaler adherence interventions in COPD: a systematic review and meta-analysis. Eur Respir Rev. 2024;33(174). Alipour A, Gabrielson S, Patel PB. Ingestible sensors and medication adherence: focus on use in serious mental illness. Pharmacy. 2020;8(2):103. Raikar AS, Kumar P, Raikar GV, Somnache SN. Advances and challenges in IoT-based smart drug delivery systems: a comprehensive review. Appl Syst Innov. 2023;6(4):62. Phiri VJ, Battas I, Semmar A, Medromi H, Moutaouakkil F. Towards enterprise-wide pharma 4.0 adoption. Sci Afr. 2025;28:e02771. Sharma D, Patel P, Shah M. A comprehensive study on Industry 4.0 in the pharmaceutical industry for sustainable development. Environ Sci Pollut Res. 2023;30(39):90088-98. Mastrantonas A, Kokkas P, Chatzopoulos A, Papoutsidakis M, Stergiou C, Vairis A, et al. Identifying the effects of Industry 4.0 in the pharmaceutical sector: achieving the sustainable development goals. Discov Sustain. 2024;5(1):460.