<?xml version="1.0" encoding="UTF-8"?><doi_batch version="4.3.7" xmlns="http://www.crossref.org/schema/4.3.7" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.crossref.org/schema/4.3.7 http://www.crossref.org/schema/deposit/crossref4.3.7.xsd">
		<head>
		<doi_batch_id>eamdacademy.org-RhQC-1790208523-c086331146</doi_batch_id>
		<timestamp>1790208523</timestamp>
		<depositor>
			<depositor_name>Eurasian Academy of Medicine and Dentistry</depositor_name>
			<email_address>info@eamdacademy.org</email_address>
		</depositor>
		<registrant>Eurasian Academy of Medicine and Dentistry</registrant>
	</head>
	<body>
		<journal>
			<journal_metadata>
				<full_title>Journal of Applied Pharmaceutical Technologies and Systems</full_title>
				<abbrev_title>J Appl Pharm Technol Syst</abbrev_title>
				<issn>3149-9589</issn>
			</journal_metadata>
			<journal_issue>
				<publication_date>
					<year>2026</year>
				</publication_date>
				<journal_volume>
					<volume>5</volume>
				</journal_volume>
				<issue>2</issue>
			</journal_issue>
			<journal_article publication_type="full_text">
				<titles>
					<title>Distinct and Combined Actions of Lead, Cadmium, and Zinc Ions on the Acid Stability of Erythrocytes in Rats: Insights from Ecotoxicology</title>
				</titles>
								<contributors>
          					<person_name sequence="first" contributor_role="author">
            <given_name>Sanjay</given_name>
            <surname>Kulkarni</surname>
					</person_name>
          					<person_name sequence="additional" contributor_role="author">
            <given_name>Meenal</given_name>
            <surname>Joshi</surname>
					</person_name>
          					<person_name sequence="additional" contributor_role="author">
            <given_name>Rohan</given_name>
            <surname>Patil</surname>
					</person_name>
          					<person_name sequence="additional" contributor_role="author">
            <given_name>Aniket</given_name>
            <surname>Deshmukh</surname>
					</person_name>
          				</contributors>
								<publication_date>
					<year>2026</year>
				</publication_date>
				<doi_data>
					<doi>10.68159/c086331146</doi>
					<resource>https://eamdacademy.org/pub/journal/3/article/c086331146</resource>
				</doi_data>
				<citation_list>
          					<citation key="rk-10.68159/c086331146-11d0b4db-c67a-4a4f-b615-46e91e4c90b0">
					  <unstructured_citation>Barnard ND, Rembert E, Freeman A, Bradshaw M, Holubkov R, Kahleova H. Blood type is not associated with changes in cardiometabolic outcomes in response to a plant-based dietary intervention. J Acad Nutr Diet. 2021;121(6):1080-6.</unstructured_citation>
						 <doi>10.1016/j.jand.2020.08.079</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-e687235b-2de7-4940-9bd6-d032087a0291">
					  <unstructured_citation>Allen LA, Terashvili M, Gifford A, Lombard JH. Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry. J Vis Exp. 2020;(155).</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/c086331146-56c294ae-8ce4-40b6-8213-b39234230d2c">
					  <unstructured_citation>Chan CY, Cheng CF, Shui HA, Ku HC, Su WL. Erythrocyte degradation, metabolism, secretion, and communication with immune cells in the blood during sepsis: a review. Tzu Chi Med J. 2021;34(2):125-33.</unstructured_citation>
						 <doi>10.4103/tcmj.tcmj_58_21</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-5edf945c-aeee-4208-8134-0f85a6be3edc">
					  <unstructured_citation>Habeeb E, Aldosari S, Saghir SA, Cheema M, Momenah T, Husain K, et al. Role of environmental toxicants in the development of hypertensive and cardiovascular diseases. Toxicol Rep. 2022;9:521-33.</unstructured_citation>
						 <doi>10.1016/j.toxrep.2022.03.019</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-82499a3f-57ca-4e97-afab-4f2cd6e70379">
					  <unstructured_citation>Orrico F, Laurance S, Lopez AC, Lefevre SD, Thomson L, Möller MN, et al. Oxidative stress in healthy and pathological red blood cells. Biomolecules. 2023;13(8):1262.</unstructured_citation>
						 <doi>10.3390/biom13081262</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-dc0d696d-6772-4859-90a6-4f3fcf83dcc6">
					  <unstructured_citation>Besedina NA, Skverchinskaya EA, Shmakov SV, Ivanov AS, Mindukshev IV, Bukatin AS. Persistent red blood cells retain their ability to move in microcapillaries under high levels of oxidative stress. Commun Biol. 2022;5(1):659.</unstructured_citation>
						 <doi>10.1038/s42003-022-03620-5</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-42df5e99-1b4c-4b15-b5d8-6bc22f465a1d">
					  <unstructured_citation>Demchenkov EL, Nagdalian AA, Budkevich RO, Oboturova NP, Okolelova AI. Usage of atomic force microscopy for detection of the damaging effect of CdCl2 on red blood cells membrane. Ecotoxicol Environ Saf. 2021;208:111683.</unstructured_citation>
						 <doi>10.1016/j.ecoenv.2020.111683</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-9664ac65-761c-434e-b944-cadb1b2692ce">
					  <unstructured_citation>Wadhwa R, Aggarwal T, Thapliyal N, Kumar A, Priya, Yadav P, et al. Red blood cells as an efficient in vitro model for evaluating the efficacy of metallic nanoparticles. 3 Biotech. 2019;9(7):279.</unstructured_citation>
						 <doi>10.1007/s13205-019-1807-4</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-310fd8f5-deaf-49d7-9627-86ec151a9556">
					  <unstructured_citation>Sae-Lee W, McCafferty CL, Verbeke EJ, Havugimana PC, Papoulas O, McWhite CD, et al. The protein organization of a red blood cell. Cell Rep. 2022;40(3):111103.</unstructured_citation>
						 <doi>10.1016/j.celrep.2022</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-7b4ea836-c2e4-4952-b039-e2af700b6712">
					  <unstructured_citation>Kuhn V, Diederich L, Keller TCS 4th, Kramer CM, Lückstädt W, Panknin C, et al. Red blood cell function and dysfunction: redox regulation, nitric oxide metabolism, anemia. Antioxid Redox Signal. 2017;26(13):718-42.</unstructured_citation>
						 <doi>10.1089/ars.2016.6954</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-74e42937-255a-4d5d-960d-8065f8aa3590">
					  <unstructured_citation>Krężel A, Maret W. The bioinorganic chemistry of mammalian metallothioneins. Chem Rev. 2021;121(23):14594-648.</unstructured_citation>
						 <doi>10.1021/acs.chemrev.1c00371</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-a422b835-64a5-4a91-9030-339b1c621233">
					  <unstructured_citation>Kim JJ, Kim YS, Kumar V. Heavy metal toxicity: an update of chelating therapeutic strategies. J Trace Elem Med Biol. 2019;54:226-31.</unstructured_citation>
						 <doi>10.1016/j.jtemb.2019.05.003</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-791655c9-977f-4c18-bfe5-27764aeacaac">
					  <unstructured_citation>Huang Q, Wan J, Nan W, Li S, He B, Peng Z. Association between manganese exposure in heavy metals mixtures and the prevalence of sarcopenia in US adults from NHANES 2011-2018. J Hazard Mater. 2024;464:133005.</unstructured_citation>
						 <doi>10.1016/j.jhazmat.2023.133005</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-980ff0e6-36ab-4502-a957-53fd33553be8">
					  <unstructured_citation>Wang M, Yan L, Dou S, Yang L, Zhang Y, Huang W, et al. Blood multiple heavy metals exposure and lung function in young adults: a prospective Cohort study in China. J Hazard Mater. 2023;459:132064.</unstructured_citation>
						 <doi>10.1016/j.jhazmat.2023.132064</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-625d10af-036f-44b5-b224-5b3153be798f">
					  <unstructured_citation>Jose A, Ray JG. Toxic heavy metals in human blood in relation to certain food and environmental samples in Kerala, South India. Environ Sci Pollut Res Int. 2018;25(8):7946-53.</unstructured_citation>
						 <doi>10.1007/s11356-017-1112-x</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-ec257cb8-78b6-4bda-a482-61799ccf85bb">
					  <unstructured_citation>Sharma GS, Bhattacharya R, Singh LR. Functional inhibition of redox regulated heme proteins: a novel mechanism towards oxidative stress induced by homocysteine. Redox Biol. 2021;46:102080.</unstructured_citation>
						 <doi>10.1016/j.redox.2021.102080</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-60891713-eae4-4dfc-88a3-19bfd4dc9d27">
					  <unstructured_citation>Donegan RK, Moore CM, Hanna DA, Reddi AR. Handling heme: the mechanisms underlying the movement of heme within and between cells. Free Radic Biol Med. 2019;133:88-100.</unstructured_citation>
						 <doi>10.1016/j.freeradbiomed.2018.08.005</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-72a6d3a0-9283-4f1f-af34-c1733ff9d100">
					  <unstructured_citation>Hosseini R, Montazerifar F, Shahraki E, Karajibani M, Mokhtari AM, Dashipour AR, et al. The effects of zinc sulfate supplementation on serum copeptin, C-reactive protein and metabolic markers in zinc-deficient diabetic patients on hemodialysis: a randomized, double-blind, placebo-controlled trial. Biol Trace Elem Res. 2022;200(1):76-83.</unstructured_citation>
						 <doi>10.1007/s12011-021-02649-7</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-4ad84857-630e-4ac4-b576-19933d45deee">
					  <unstructured_citation>Hu B, He PY, Zhong NN, Gao ZM, Guo JL, Feng JT, et al. Blood lead and high-density lipoprotein concentrations in relation to human blood pressure: a cross sectional study. Front Nutr. 2022;9:899780.</unstructured_citation>
						 <doi>10.3389/fnut.2022.899780</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-41632be1-397f-44a7-9008-bae306ec13b7">
					  <unstructured_citation>Khan R, Ali S, Mumtaz S, Andleeb S, Ulhaq M, Tahir HM, et al. Toxicological effects of toxic metals (cadmium and mercury) on blood and the thyroid gland and pharmacological intervention by vitamin C in rabbits. Environ Sci Pollut Res Int. 2019;26(16):16727-41.</unstructured_citation>
						 <doi>10.1007/s11356-019-04886-9</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-bdc51770-d282-4b07-a4c2-8b92530dfd73">
					  <unstructured_citation>Ngoc NTM, Chuyen NV, Thao NTT, Duc NQ, Trang NTT, Binh NTT, et al. Chromium, Cadmium, Lead, and Arsenic concentrations in water, vegetables, and seafood consumed in a Coastal Area in Northern Vietnam. Environ Health Insights. 2020;14:1178630220921410.</unstructured_citation>
						 <doi>10.1177/1178630220921410</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-326a32cd-0829-4bf9-9090-37817ea51a71">
					  <unstructured_citation>Sall ML, Diaw AKD, Gningue-Sall D, Efremova Aaron S, Aaron JJ. Toxic heavy metals: impact on the environment and human health, and treatment with conducting organic polymers, a review. Environ Sci Pollut Res Int. 2020;27(24):29927-42.</unstructured_citation>
						 <doi>10.1007/s11356-020-09354-3</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-fef7541f-d410-42a1-8333-d50c34a8ca5e">
					  <unstructured_citation>Abd Elnabi MK, Elkaliny NE, Elyazied MM, Azab SH, Elkhalifa SA, Elmasry S, et al. Toxicity of heavy metals and recent advances in their removal: a review. Toxics. 2023;11(7):580.</unstructured_citation>
						 <doi>10.3390/toxics11070580</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-a6a49246-2b4e-41cc-8b3c-e4629b4628b0">
					  <unstructured_citation>Yu S, Ye Y, Wuren T, Yi H. Alteration in the number, morphology, function, and metabolism of erythrocytes in high-altitude polycythemia. Front Physiol. 2024;15:1359357.</unstructured_citation>
						 <doi>10.3389/fphys.2024.1359357</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-d2ddcf48-8b56-4120-808d-ab85abbeef17">
					  <unstructured_citation>Koga M, Kameyama M, Okumiya T. Estimation of mean erythrocyte age using HbA1c or HbA1c/glycated albumin for evaluation of anemia severity. J Clin Lab Anal. 2023;37(13-14):e24947.</unstructured_citation>
						 <doi>10.1002/jcla.24947</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-b22f3df7-0db2-4611-a1d1-a85df44d2231">
					  <unstructured_citation>Notariale R, Infantino R, Palazzo E, Manna C. Erythrocytes as a model for heavy metal-related vascular dysfunction: The protective effect of dietary components. Int J Mol Sci. 2021;22(12):6604.</unstructured_citation>
						 <doi>10.3390/ijms22126604</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-c69aa9e8-cc00-4d91-984f-01e33aeab1bc">
					  <unstructured_citation>Amiri P, DeCastro J, Littig J, Lu HW, Liu C, Conboy I, et al. Erythrocytes, a new contributor to age-associated loss of blood-brain barrier integrity. Adv Sci (Weinh). 2021;8(20):e2101912.</unstructured_citation>
						 <doi>10.1002/advs.202101912</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-7edf7a6f-9d1b-498c-919a-bed224cbfe0d">
					  <unstructured_citation>Brun JF, Varlet-Marie E, Myzia J, Raynaud de Mauverger E, Pretorius E. Metabolic influences modulating erythrocyte deformability and eryptosis. Metabolites. 2021;12(1):4.</unstructured_citation>
						 <doi>10.3390/metabo12010004</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-e4c93814-7584-49fd-bede-a60c9b7a8725">
					  <unstructured_citation>Massaccesi L, Galliera E, Corsi Romanelli MM. Erythrocytes as markers of oxidative stress related pathologies. Mech Ageing Dev. 2020;191:111333.</unstructured_citation>
						 <doi>10.1016/j.mad.2020.111333</doi> 					</citation>
          					<citation key="rk-10.68159/c086331146-864e59b3-af95-4446-8c76-217077577134">
					  <unstructured_citation>Alves-Rosa MF, Tayler NM, Dorta D, Coronado LM, Spadafora C. P. falciparum invasion and erythrocyte aging. Cells. 2024;13(4):334.</unstructured_citation>
						 <doi>10.3390/cells13040334</doi> 					</citation>
          				</citation_list>
			</journal_article>
		</journal>
	</body>
</doi_batch>
